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Amphotericin-B entrapped lecithin/chitosan nanoparticles for prolonged ocular application

หน่วยงาน Central Drug Research Institute (CDRI), India

รายละเอียด

ชื่อเรื่อง : Amphotericin-B entrapped lecithin/chitosan nanoparticles for prolonged ocular application
นักวิจัย : Chhonker, Y S , Prasad, Y D , Chandasana, Hardik , Vishvkarma, Akhilesh , Mitra, Kalyan , Shukla, P K , Bhatta, R S
คำค้น : Fungal keratitis , Amphotericin-B , Lecithin/chitosan nanoparticles
หน่วยงาน : Central Drug Research Institute (CDRI), India
ผู้ร่วมงาน : -
ปีพิมพ์ : 2558
อ้างอิง : International Journal of Biological Macromolecules, 2015, 72, 1451–1458 , http://hdl.handle.net/123456789/1451
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CSIR-CDRI Communication No. 8807
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Fungal keratitis is the major cause of vision loss worldwide. Amphotericin-B is considered as the drug of choice for fungal infections. However, its use in ophthalmic drug delivery is limited by the low precorneal residence at ocular surface as a result of blinking reflex, tear turnover and nasopharyngeal drainage. We report Amphotericn-B loaded lecithin/chitosan nanoparticles for prolonged ocular application. The prepared nanoparticles were in the size range of 161.9–230.5 nm, entrapment efficiency of 70–75%, theoretical drug loading of 5.71% with positive zeta potential of 26.6–38.3 mV. As demonstrated by antifungal susceptibility against Candida albicans and Aspergillus fumigatus, nanoparticles were more effective than marketed formulation. They exhibited pronounced mucoadhesive properties. In-vivo pharmacokinetic studies in New Zealand albino rabbit eyes indicated improved bioavailablity (~2.04 fold) and precorneal residence time (~3.36 fold) of nanoparticles prepared from low molecular weight of chitosan as compared with marketed formulation.

บรรณานุกรม :
Chhonker, Y S , Prasad, Y D , Chandasana, Hardik , Vishvkarma, Akhilesh , Mitra, Kalyan , Shukla, P K , Bhatta, R S . (2558). Amphotericin-B entrapped lecithin/chitosan nanoparticles for prolonged ocular application.
    : Central Drug Research Institute (CDRI), India.
Chhonker, Y S , Prasad, Y D , Chandasana, Hardik , Vishvkarma, Akhilesh , Mitra, Kalyan , Shukla, P K , Bhatta, R S . 2558. "Amphotericin-B entrapped lecithin/chitosan nanoparticles for prolonged ocular application".
    : Central Drug Research Institute (CDRI), India.
Chhonker, Y S , Prasad, Y D , Chandasana, Hardik , Vishvkarma, Akhilesh , Mitra, Kalyan , Shukla, P K , Bhatta, R S . "Amphotericin-B entrapped lecithin/chitosan nanoparticles for prolonged ocular application."
    : Central Drug Research Institute (CDRI), India, 2558. Print.
Chhonker, Y S , Prasad, Y D , Chandasana, Hardik , Vishvkarma, Akhilesh , Mitra, Kalyan , Shukla, P K , Bhatta, R S . Amphotericin-B entrapped lecithin/chitosan nanoparticles for prolonged ocular application. : Central Drug Research Institute (CDRI), India; 2558.