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Osteogenic activity of natural diterpenoids in calvarial derived osteoblast cells via differentiation and mineralization

หน่วยงาน Central Drug Research Institute (CDRI), India

รายละเอียด

ชื่อเรื่อง : Osteogenic activity of natural diterpenoids in calvarial derived osteoblast cells via differentiation and mineralization
นักวิจัย : Khan, M F , Dev, Kapil , Lahiri, Shibani , Dixit, Manisha , Trivedi, Ritu , Singh, Divya , Maurya, Rakesh
คำค้น : Alkaline phosphatase , Cupressus sempervirens , Diterpenoids , Osteoblast differentiation , Osteoporosis , Sugiol
หน่วยงาน : Central Drug Research Institute (CDRI), India
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Phytomedicine, 2014, 21(14), 1794-800 , http://hdl.handle.net/123456789/1449
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CSIR-CDRI Communication No. 8804
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The aim of the present study was to investigate the antiosteoporotic activity of four structurally related diterpenoids: sugiol (1), trans-communic acid (2), 15-acetoxy imbricatolic acid (3) and imbricatolic acid (4). Their osteogenic effect was evaluated by using validated models including alkaline phosphatase (ALP) assay, mineralization assay and expression of osteogenic genes-bone morphogenetic protein-2(BMP2) and osteoblast transcription factor (RUNX2) – in primary calvarial cultures harvested from neonatal mice. Among them, compound 1 at a dose of 1.0 mg/kg body weight exhibited significant osteoprotective effects and did not show uterine estrogenicity at the same dose. Additionally, compound 1 treatment led to improved biomechanical properties as exhibited by increased power, energy and stiffness in femoral bones compared to untreated Ovx animals. Since osteoporotic compression fracture correlates with the mechanical characteristics of trabecular bone, so that it could effectively reduce the risk of this type of fracture by improving trabecular micro architecture in postmenopausal women. Therefore, our findings proposed that diterpenoids may be useful new chemical agents in the treatment of diseases associated with bone lose

บรรณานุกรม :
Khan, M F , Dev, Kapil , Lahiri, Shibani , Dixit, Manisha , Trivedi, Ritu , Singh, Divya , Maurya, Rakesh . (2557). Osteogenic activity of natural diterpenoids in calvarial derived osteoblast cells via differentiation and mineralization.
    : Central Drug Research Institute (CDRI), India.
Khan, M F , Dev, Kapil , Lahiri, Shibani , Dixit, Manisha , Trivedi, Ritu , Singh, Divya , Maurya, Rakesh . 2557. "Osteogenic activity of natural diterpenoids in calvarial derived osteoblast cells via differentiation and mineralization".
    : Central Drug Research Institute (CDRI), India.
Khan, M F , Dev, Kapil , Lahiri, Shibani , Dixit, Manisha , Trivedi, Ritu , Singh, Divya , Maurya, Rakesh . "Osteogenic activity of natural diterpenoids in calvarial derived osteoblast cells via differentiation and mineralization."
    : Central Drug Research Institute (CDRI), India, 2557. Print.
Khan, M F , Dev, Kapil , Lahiri, Shibani , Dixit, Manisha , Trivedi, Ritu , Singh, Divya , Maurya, Rakesh . Osteogenic activity of natural diterpenoids in calvarial derived osteoblast cells via differentiation and mineralization. : Central Drug Research Institute (CDRI), India; 2557.