| ชื่อเรื่อง | : | Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents |
| นักวิจัย | : | Ramakrishna, K K G , Gunjan, Sarika , Shukla, A K , Pasam, V R , Balaramnavar, V M , Sharma, Abhisheak , Jaiswal, Swati , Lal, Jawahar , Tripathi, Renu , Srivastava, Anubhooti , Ramachandran, Ravishankar , Tripathi, R P |
| คำค้น | : | Antimalarial agent , Phenyl sulfonamides , Diarylureides , Plasmodium falciparum |
| หน่วยงาน | : | Central Drug Research Institute (CDRI), India |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2557 |
| อ้างอิง | : | ACS Medicinal Chemistry Letters, 2014, 5 (8), 878–883 , http://hdl.handle.net/123456789/1442 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | CSIR-CDRI communication No. 8709 |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | A new series of C- linked phenyl butenonyl glycosides bearing ureidyl(thioureidyl) and sulfonamidyl moieties in the phenyl rings were designed, synthesized and evaluated for their in vitro antimalarial activities against Plasmodium falciparum 3D7 (CQ sensitive) and K1 (CQ resistant) strains. Among all the compounds screened the C- linked phenyl butenonyl glycosides bearing sulfonamidyl moiety (5a) and ureidyl moiety in the phenyl ring (7d and 8c) showed promising antimalarial activities against both 3D7 and K1 strains with IC50 values in µM range and low cytotoxicity offering new HITS for further exploration |
| บรรณานุกรม | : |
Ramakrishna, K K G , Gunjan, Sarika , Shukla, A K , Pasam, V R , Balaramnavar, V M , Sharma, Abhisheak , Jaiswal, Swati , Lal, Jawahar , Tripathi, Renu , Srivastava, Anubhooti , Ramachandran, Ravishankar , Tripathi, R P . (2557). Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents.
: Central Drug Research Institute (CDRI), India. Ramakrishna, K K G , Gunjan, Sarika , Shukla, A K , Pasam, V R , Balaramnavar, V M , Sharma, Abhisheak , Jaiswal, Swati , Lal, Jawahar , Tripathi, Renu , Srivastava, Anubhooti , Ramachandran, Ravishankar , Tripathi, R P . 2557. "Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents".
: Central Drug Research Institute (CDRI), India. Ramakrishna, K K G , Gunjan, Sarika , Shukla, A K , Pasam, V R , Balaramnavar, V M , Sharma, Abhisheak , Jaiswal, Swati , Lal, Jawahar , Tripathi, Renu , Srivastava, Anubhooti , Ramachandran, Ravishankar , Tripathi, R P . "Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents."
: Central Drug Research Institute (CDRI), India, 2557. Print. Ramakrishna, K K G , Gunjan, Sarika , Shukla, A K , Pasam, V R , Balaramnavar, V M , Sharma, Abhisheak , Jaiswal, Swati , Lal, Jawahar , Tripathi, Renu , Srivastava, Anubhooti , Ramachandran, Ravishankar , Tripathi, R P . Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents. : Central Drug Research Institute (CDRI), India; 2557.
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