ชื่อเรื่อง | : | Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents |
นักวิจัย | : | Sharma, Smriti , Saquib, Mohammad , Verma, Saroj , Mishra, N N , Shukla, P K , Srivastava, Ranjana , Prabhakar, Y S , Shaw, A K |
คำค้น | : | 2,3,6-Trideoxy Sugars , 1,2,3-Triazole , Molecular Hybridization , Click Chemistry , Antimicrobial Agents , Penicillin binding protein |
หน่วยงาน | : | Central Drug Research Institute (CDRI), India |
ผู้ร่วมงาน | : | - |
ปีพิมพ์ | : | 2557 |
อ้างอิง | : | European Journal of Medicinal Chemistry, 2014, 83, 474-89 , http://hdl.handle.net/123456789/1413 |
ที่มา | : | - |
ความเชี่ยวชาญ | : | - |
ความสัมพันธ์ | : | CSIR-CDRI Communication No. 8723 |
ขอบเขตของเนื้อหา | : | - |
บทคัดย่อ/คำอธิบาย | : | Here, we describe a molecular hybridization inspired design and synthesis of novel 6-triazolyl 2,3,6-trideoxy sugars as promising new broad-spectrum antimicrobial agents using click chemistry in key step. These compounds showed MIC between 0.39-50µg/mL against different native and resistant bacteria and fungi with no toxicity. Among them, compound 29 was the most active molecule with MIC 0.78µg/mL against Staphylococcus aureus and Klebsiella pneumoniae and 3.12µg/mL against methicillin- and vancomycin-resistant S. aureus. Compound 26 was the most potent anti-fungal candidate with MIC 0.39µg/mL against T. mentagrophytes. Compound 46 was found to be promising with broad-spectrum activity against both bacterial and fungal strains. The bioinformatic studies involving bacteria’s protein co-crystals prompted penicillin binding protein-2 as the most likely target of these compounds. |
บรรณานุกรม | : |
Sharma, Smriti , Saquib, Mohammad , Verma, Saroj , Mishra, N N , Shukla, P K , Srivastava, Ranjana , Prabhakar, Y S , Shaw, A K . (2557). Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents.
: Central Drug Research Institute (CDRI), India. Sharma, Smriti , Saquib, Mohammad , Verma, Saroj , Mishra, N N , Shukla, P K , Srivastava, Ranjana , Prabhakar, Y S , Shaw, A K . 2557. "Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents".
: Central Drug Research Institute (CDRI), India. Sharma, Smriti , Saquib, Mohammad , Verma, Saroj , Mishra, N N , Shukla, P K , Srivastava, Ranjana , Prabhakar, Y S , Shaw, A K . "Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents."
: Central Drug Research Institute (CDRI), India, 2557. Print. Sharma, Smriti , Saquib, Mohammad , Verma, Saroj , Mishra, N N , Shukla, P K , Srivastava, Ranjana , Prabhakar, Y S , Shaw, A K . Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents. : Central Drug Research Institute (CDRI), India; 2557.
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