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Synthesis and Biological Evaluation of Chalcones as Potential Antileishmanial Agents

หน่วยงาน Central Drug Research Institute (CDRI), India

รายละเอียด

ชื่อเรื่อง : Synthesis and Biological Evaluation of Chalcones as Potential Antileishmanial Agents
นักวิจัย : Gupta, Shweta , Shivahare, Rahul , Korthikunta, Venkateswarlu , Singh, Rohit , Gupta, Suman , Tadigoppula, Narender
คำค้น : Chromenochalcones , Chromenodihydrochalcones , Antileishmanial , Leishmania donovani / Hamster model
หน่วยงาน : Central Drug Research Institute (CDRI), India
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : European Journal of Medicinal Chemistry, 2014, 23, 81, 359-66 , http://hdl.handle.net/123456789/1386
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CSIR-CDRI Communication No. 8693
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Antileishmanial activities of thirty five synthetic chalcones have been examined. Among them, ten compounds (4, 6, 16, 22, 23, 24, 25, 29, 35 and 37) exhibited potent in vitro activity (IC50 range from 1.70 to 8 µM) against extracellular promastigotes and intracellular amastigotes form of Leishmania donovani. Two promising compounds 22 and 37 were tested in vivo in L. donovani / hamster model. Chalcone 37 showed 83.32% parasite inhibition at a dose of 50 mg/kg for 10 days whereas, 75.89% parasite inhibition at 100 mg/kg dose for 5 days by intraperitoneal route at day 7 post-treatment.

บรรณานุกรม :
Gupta, Shweta , Shivahare, Rahul , Korthikunta, Venkateswarlu , Singh, Rohit , Gupta, Suman , Tadigoppula, Narender . (2557). Synthesis and Biological Evaluation of Chalcones as Potential Antileishmanial Agents.
    : Central Drug Research Institute (CDRI), India.
Gupta, Shweta , Shivahare, Rahul , Korthikunta, Venkateswarlu , Singh, Rohit , Gupta, Suman , Tadigoppula, Narender . 2557. "Synthesis and Biological Evaluation of Chalcones as Potential Antileishmanial Agents".
    : Central Drug Research Institute (CDRI), India.
Gupta, Shweta , Shivahare, Rahul , Korthikunta, Venkateswarlu , Singh, Rohit , Gupta, Suman , Tadigoppula, Narender . "Synthesis and Biological Evaluation of Chalcones as Potential Antileishmanial Agents."
    : Central Drug Research Institute (CDRI), India, 2557. Print.
Gupta, Shweta , Shivahare, Rahul , Korthikunta, Venkateswarlu , Singh, Rohit , Gupta, Suman , Tadigoppula, Narender . Synthesis and Biological Evaluation of Chalcones as Potential Antileishmanial Agents. : Central Drug Research Institute (CDRI), India; 2557.