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Synthesis and antifilarial activity of chalcone-thiazole derivatives against a human lymphatic filarial parasite, Brugia malayi

หน่วยงาน Central Drug Research Institute (CDRI), India

รายละเอียด

ชื่อเรื่อง : Synthesis and antifilarial activity of chalcone-thiazole derivatives against a human lymphatic filarial parasite, Brugia malayi
นักวิจัย : Sashidhara, K V , Rao, K B , Kushwaha, Vikas , Modukuri, R K , Verma, Richa , Murthy, P K
คำค้น : Brugia malayi , Microfilariae , Macrofilariae , Diethylcarbamazine , Albendazole , Ivermectin
หน่วยงาน : Central Drug Research Institute (CDRI), India
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : European Journal of Medicinal Chemistry, 2014, 81, 473-80 , http://hdl.handle.net/123456789/1385
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CSIR-CDRI Communication No.8684
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Here we report the synthesis of novel chalcone-thiazole compounds and their antifilarial activity. The antifilarial properties of these hybrids were assessed against microfilariae as well as adult worms of Brugia malayi. Among all the synthesized compounds, only two compounds, namely 4g and 4n were identified to be promising in vitro. These active compounds were tested in B. malayi-jird (Meriones unguiculatus) and B. malayi- Mastomys coucha models. Compound 4n showed 100% embryostatic effect and 49% macrofilaricidal in jirds and M. coucha models, respectively. This study provides a new structural clue for the development of novel antifilarial lead molecules.

บรรณานุกรม :
Sashidhara, K V , Rao, K B , Kushwaha, Vikas , Modukuri, R K , Verma, Richa , Murthy, P K . (2557). Synthesis and antifilarial activity of chalcone-thiazole derivatives against a human lymphatic filarial parasite, Brugia malayi.
    : Central Drug Research Institute (CDRI), India.
Sashidhara, K V , Rao, K B , Kushwaha, Vikas , Modukuri, R K , Verma, Richa , Murthy, P K . 2557. "Synthesis and antifilarial activity of chalcone-thiazole derivatives against a human lymphatic filarial parasite, Brugia malayi".
    : Central Drug Research Institute (CDRI), India.
Sashidhara, K V , Rao, K B , Kushwaha, Vikas , Modukuri, R K , Verma, Richa , Murthy, P K . "Synthesis and antifilarial activity of chalcone-thiazole derivatives against a human lymphatic filarial parasite, Brugia malayi."
    : Central Drug Research Institute (CDRI), India, 2557. Print.
Sashidhara, K V , Rao, K B , Kushwaha, Vikas , Modukuri, R K , Verma, Richa , Murthy, P K . Synthesis and antifilarial activity of chalcone-thiazole derivatives against a human lymphatic filarial parasite, Brugia malayi. : Central Drug Research Institute (CDRI), India; 2557.