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Beneficial effects of Nebivolol in comparison with Atenolol on safety and tolerability in essential hypertension

หน่วยงาน Central Drug Research Institute (CDRI), India

รายละเอียด

ชื่อเรื่อง : Beneficial effects of Nebivolol in comparison with Atenolol on safety and tolerability in essential hypertension
นักวิจัย : Bhosale, V V , Inamdar, S C , Karande, V B , Burute, S R , Murthy, M B , Ghatak, A
คำค้น : Hypertension , Nebivolol , Atenolol
หน่วยงาน : Central Drug Research Institute (CDRI), India
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Journal of Clinical and Diagnostic Research, 2014, 8 (6), HC01 - HC04 , http://hdl.handle.net/123456789/1384
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CSIR-CDRI Communication No. 8682
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Introduction: Hypertension, “The silent killer” is a multifactorial disorder which is asymptomatic and if left untreated leads to lethal complications. Nebivolol is a third generation beta blocker with additional vasodilating property due to nitric oxide release. Aim: The current study aims to assess efficacy and safety of Nebivolol and compare with Atenolol. Methods: This was prospective, double blind, comparative controlled clinical study. Total 90 patients were enrolled into study as per selection criteria. Patients were randomized to receive Atenolol and Nebivolol with 45 patients in each group for twelve week. Results and Conclusion: The mean reduction diastolic blood pressure in Nebivolol and Atenolol group was 10.77±2.60 and 10.05±2.83 respectively. The number of patients with adverse effect events was higher in the Atenolol than in the Nebivolol group (36.84% of Atenolol Vs 12.82% of Nebivolol). Thus it can be concluded that, for the same antihypertensive effect, Nebivolol was better tolerated than Atenolol.

บรรณานุกรม :
Bhosale, V V , Inamdar, S C , Karande, V B , Burute, S R , Murthy, M B , Ghatak, A . (2557). Beneficial effects of Nebivolol in comparison with Atenolol on safety and tolerability in essential hypertension.
    : Central Drug Research Institute (CDRI), India.
Bhosale, V V , Inamdar, S C , Karande, V B , Burute, S R , Murthy, M B , Ghatak, A . 2557. "Beneficial effects of Nebivolol in comparison with Atenolol on safety and tolerability in essential hypertension".
    : Central Drug Research Institute (CDRI), India.
Bhosale, V V , Inamdar, S C , Karande, V B , Burute, S R , Murthy, M B , Ghatak, A . "Beneficial effects of Nebivolol in comparison with Atenolol on safety and tolerability in essential hypertension."
    : Central Drug Research Institute (CDRI), India, 2557. Print.
Bhosale, V V , Inamdar, S C , Karande, V B , Burute, S R , Murthy, M B , Ghatak, A . Beneficial effects of Nebivolol in comparison with Atenolol on safety and tolerability in essential hypertension. : Central Drug Research Institute (CDRI), India; 2557.