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Synthesis of novel β-carboline based chalcones with high cytotoxic activity against breast cancer cells

หน่วยงาน Central Drug Research Institute (CDRI), India

รายละเอียด

ชื่อเรื่อง : Synthesis of novel β-carboline based chalcones with high cytotoxic activity against breast cancer cells
นักวิจัย : Chauhan, S S , Singh, A K , Meena, Sanjeev , Lohani, Minaxi , Singh, Akhilesh , Arya, R K , Cheruvu, S H , Sarkar, Jayanta , Gayen, J R , Datta, Dipak , Chauhan, P M S
คำค้น : Anticancer , β-carboline , Chalcone , Cytotoxic
หน่วยงาน : Central Drug Research Institute (CDRI), India
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Bioorganic & Medicinal Chemistry Letters, 2014, 24(13):2820-4 , http://hdl.handle.net/123456789/1383
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CSIR-CDRI Communication No. 8690
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

A series of novel β-carboline based chalcones was synthesized and evaluated for their cytotoxic activity against a panel of human cancer cell lines. Among them we found that two of the compounds 7c and 7d, showed marked anti-proliferative activity in a panel of solid tumor cell lines with highest effect in breast cancer. The compounds 7c and 7d showed an IC50 of 2.25 and 3.29 µM respectively against human breast cancer MCF-7 cell line. Further, the compound 7c markedly induced DNA fragmentation and apoptosis in breast cancer cells.

บรรณานุกรม :
Chauhan, S S , Singh, A K , Meena, Sanjeev , Lohani, Minaxi , Singh, Akhilesh , Arya, R K , Cheruvu, S H , Sarkar, Jayanta , Gayen, J R , Datta, Dipak , Chauhan, P M S . (2557). Synthesis of novel β-carboline based chalcones with high cytotoxic activity against breast cancer cells.
    : Central Drug Research Institute (CDRI), India.
Chauhan, S S , Singh, A K , Meena, Sanjeev , Lohani, Minaxi , Singh, Akhilesh , Arya, R K , Cheruvu, S H , Sarkar, Jayanta , Gayen, J R , Datta, Dipak , Chauhan, P M S . 2557. "Synthesis of novel β-carboline based chalcones with high cytotoxic activity against breast cancer cells".
    : Central Drug Research Institute (CDRI), India.
Chauhan, S S , Singh, A K , Meena, Sanjeev , Lohani, Minaxi , Singh, Akhilesh , Arya, R K , Cheruvu, S H , Sarkar, Jayanta , Gayen, J R , Datta, Dipak , Chauhan, P M S . "Synthesis of novel β-carboline based chalcones with high cytotoxic activity against breast cancer cells."
    : Central Drug Research Institute (CDRI), India, 2557. Print.
Chauhan, S S , Singh, A K , Meena, Sanjeev , Lohani, Minaxi , Singh, Akhilesh , Arya, R K , Cheruvu, S H , Sarkar, Jayanta , Gayen, J R , Datta, Dipak , Chauhan, P M S . Synthesis of novel β-carboline based chalcones with high cytotoxic activity against breast cancer cells. : Central Drug Research Institute (CDRI), India; 2557.