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Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in cryptococcus neoformans

หน่วยงาน Nanyang Technological University, Singapore

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ชื่อเรื่อง : Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in cryptococcus neoformans
นักวิจัย : Ero, Rya , Dimitrova, Valya Tenusheva , Chen, Yun , Bu, Wenting , Feng, Shu , Liu, Tongbao , Wang, Ping , Xue, Chaoyang , Tan, Suet Mien , Gao, Yong-Gui
คำค้น : DRNTU::Science::Biological sciences
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2558
อ้างอิง : Ero, R., Dimitrova, V. T., Chen, Y., Bu, W., Feng, S., Liu, T., et al. (2015). Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in cryptococcus neoformans. Scientific reports, 5, 8688-. , 2045-2322 , http://hdl.handle.net/10220/25268 , http://dx.doi.org/10.1038/srep08688
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Scientific reports
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The atypical Gβ-like/RACK1 Gib2 protein promotes cAMP signalling that plays a central role in regulating the virulence of Cryptococcus neoformans. Gib2 contains a seven-bladed β transducin structure and is emerging as a scaffold protein interconnecting signalling pathways through interactions with various protein partners. Here, we present the crystal structure of Gib2 at a 2.2-Å resolution. The structure allows us to analyse the association between Gib2 and the ribosome, as well as to identify the Gib2 amino acid residues involved in ribosome binding. Our studies not only suggest that Gib2 has a role in protein translation but also present Gib2 as a physical link at the crossroads of various regulatory pathways important for the growth and virulence of C. neoformans.

บรรณานุกรม :
Ero, Rya , Dimitrova, Valya Tenusheva , Chen, Yun , Bu, Wenting , Feng, Shu , Liu, Tongbao , Wang, Ping , Xue, Chaoyang , Tan, Suet Mien , Gao, Yong-Gui . (2558). Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in cryptococcus neoformans.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Ero, Rya , Dimitrova, Valya Tenusheva , Chen, Yun , Bu, Wenting , Feng, Shu , Liu, Tongbao , Wang, Ping , Xue, Chaoyang , Tan, Suet Mien , Gao, Yong-Gui . 2558. "Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in cryptococcus neoformans".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Ero, Rya , Dimitrova, Valya Tenusheva , Chen, Yun , Bu, Wenting , Feng, Shu , Liu, Tongbao , Wang, Ping , Xue, Chaoyang , Tan, Suet Mien , Gao, Yong-Gui . "Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in cryptococcus neoformans."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2558. Print.
Ero, Rya , Dimitrova, Valya Tenusheva , Chen, Yun , Bu, Wenting , Feng, Shu , Liu, Tongbao , Wang, Ping , Xue, Chaoyang , Tan, Suet Mien , Gao, Yong-Gui . Crystal structure of Gib2, a signal-transducing protein scaffold associated with ribosomes in cryptococcus neoformans. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2558.