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Designed di-heme binding helical transmembrane protein

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Designed di-heme binding helical transmembrane protein
นักวิจัย : Mahajan, Mukesh , Bhattacharjya, Surajit
คำค้น : DRNTU::Science::Biological sciences
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Mahajan, M., & Bhattacharjya, S. (2014). Designed di-heme binding helical transmembrane protein. ChemBioChem, 15(9), 1257-1262. , 1439-4227 , http://hdl.handle.net/10220/20460 , http://dx.doi.org/10.1002/cbic.201402142
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : ChemBioChem
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

De novo designing of functional membrane proteins is fundamental in terms of understanding the structure, folding, and stability of membrane proteins. In this work, we report the design and characterization of a transmembrane protein, termed HETPRO (HEme-binding Transmembrane PROtein), that binds two molecules of heme in a membrane and catalyzes oxidation/reduction reactions. The primary structure of HETPRO has been optimized in a guided fashion, from an antimicrobial peptide, for transmembrane orientation, defined 3D structure, and functions. HETPRO assembles into a tetrameric form, from an apo dimeric helical structure, in complex with cofactor in detergent micelles. The NMR structure of the apo HETPRO in micelles reveals an antiparallel helical dimer that inserts into the nonpolar core of detergent micelles. The well-defined structure of HETPRO and its ability to bind to heme moieties could be utilized to develop a functional membrane protein mimic for electron transport and photosystems.

บรรณานุกรม :
Mahajan, Mukesh , Bhattacharjya, Surajit . (2557). Designed di-heme binding helical transmembrane protein.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Mahajan, Mukesh , Bhattacharjya, Surajit . 2557. "Designed di-heme binding helical transmembrane protein".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Mahajan, Mukesh , Bhattacharjya, Surajit . "Designed di-heme binding helical transmembrane protein."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Mahajan, Mukesh , Bhattacharjya, Surajit . Designed di-heme binding helical transmembrane protein. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.