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Effects of Calophyllum inophyllum fruit extract on the proliferation and morphological characteristics of human breast cancer cells MCF-7

หน่วยงาน Universiti Sains Malaysia, Malaysia

รายละเอียด

ชื่อเรื่อง : Effects of Calophyllum inophyllum fruit extract on the proliferation and morphological characteristics of human breast cancer cells MCF-7
นักวิจัย : Perumal, Shanmugapriya , Yeng, Chen , Kanwar, Jagat Rakesh , Sasidharan, Sreenivasan
คำค้น : R735-854 Medical education. Medical schools. Research
หน่วยงาน : Universiti Sains Malaysia, Malaysia
ผู้ร่วมงาน : -
ปีพิมพ์ : 2559
อ้างอิง : Perumal, Shanmugapriya and Yeng, Chen and Kanwar, Jagat Rakesh and Sasidharan, Sreenivasan (2016) Effects of Calophyllum inophyllum fruit extract on the proliferation and morphological characteristics of human breast cancer cells MCF-7. Asian Pacific Journal of Tropical Disease, 6 (4). pp. 291-297. ISSN 2222-1808
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : https://doi.org/10.1016/S2222-1808(15)61033-7 , http://eprints.usm.my/36912/
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Objective: To evaluate the antiproliferative activity of Calophyllum inophyllum (C. inophyllum) fruit extract against human breast cancer cells MCF-7. Methods: The cytotoxic effect of C. inophyllum fruit extract against MCF-7 cancer cells was evaluated through MTT and CyQuant assays for 24 h and the morphological investigation of treated MCF-7 cells was observed under optical microscope using Giemsa staining. Results: The cytotoxic effect of C. inophyllum fruit extract against MCF-7 cancer cells was evaluated through MTT and CyQuant assays simultaneously for 24 h after treatment, which demonstrated the inhibition of cell viability with the IC50 values of 19.63 μg/mL and 27.54 μg/mL, respectively. The preliminary time-based morphological investigation of MCF-7 cells treated with the IC50 value (23.59 μg/mL) of C. inophyllum fruit extract was observed under an optical microscopy via Giemsa staining, which exhibited prominent histological characteristics of apoptosis. Conclusions: This study clearly proved that the proliferation of human breast cancer cell MCF-7 was inhibited by C. inophyllum fruit extract resulted from the induction of apoptosis in MCF-7 cells.

บรรณานุกรม :
Perumal, Shanmugapriya , Yeng, Chen , Kanwar, Jagat Rakesh , Sasidharan, Sreenivasan . (2559). Effects of Calophyllum inophyllum fruit extract on the proliferation and morphological characteristics of human breast cancer cells MCF-7.
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia.
Perumal, Shanmugapriya , Yeng, Chen , Kanwar, Jagat Rakesh , Sasidharan, Sreenivasan . 2559. "Effects of Calophyllum inophyllum fruit extract on the proliferation and morphological characteristics of human breast cancer cells MCF-7".
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia.
Perumal, Shanmugapriya , Yeng, Chen , Kanwar, Jagat Rakesh , Sasidharan, Sreenivasan . "Effects of Calophyllum inophyllum fruit extract on the proliferation and morphological characteristics of human breast cancer cells MCF-7."
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia, 2559. Print.
Perumal, Shanmugapriya , Yeng, Chen , Kanwar, Jagat Rakesh , Sasidharan, Sreenivasan . Effects of Calophyllum inophyllum fruit extract on the proliferation and morphological characteristics of human breast cancer cells MCF-7. กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia; 2559.