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In-vitro evaluation of Bacopa monniera extract and individual constituents on human recombinant Monoamine oxidase enzymes

หน่วยงาน Central Drug Research Institute (CDRI), India

รายละเอียด

ชื่อเรื่อง : In-vitro evaluation of Bacopa monniera extract and individual constituents on human recombinant Monoamine oxidase enzymes
นักวิจัย : Singh, Rajbir , Ramakrishna, Rachumallu , Bhateria, Manisha , Bhatta, R S
คำค้น : Bacopa monniera , Monoamine oxidase enzymes
หน่วยงาน : Central Drug Research Institute (CDRI), India
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Phytotherapy Research, 2014, 28 (9), 1419–1422 , http://hdl.handle.net/123456789/1427
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CSIR-CDRI Communication No. 8590
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Bacopa monniera (BM) is a traditional Ayurvedic medicinal plant that has been used worldwide for its nootropic action. Chemically standardized extract of BM is now available as over the counter herbal remedy to enhance memory in children and adults. Considering the nootropic action of BM, we evaluated the effect of clinically available BM extract and six of BM constituents (bacoside A3, bacopaside I, bacopaside II, bacosaponin C, bacosine and bacoside A mixture) on recombinant human monoamine oxidase enzymes. Effect of BM extract and individual constituents on human recombinant MAO-A and MAO-B enzymes were evaluated using MAO-GloTM assay kit (Promega corporation,USA), following the instructional manual. IC50 and mode of inhibition was measured for MAO enzymes. Bacopaside I and bacoside A mix inhibited the MAO-A and MAO-B enzymes. Bacopaside I exhibited mixed mode of inhibition with IC50 and Ki value of 17.08 ± 1.64 and 42.5 ± 3.53 µg/mL, respectively for MAO-A enzyme. Bacopaside I is the major constituent of BM that inhibited the MAO-A enzyme selectively.

บรรณานุกรม :
Singh, Rajbir , Ramakrishna, Rachumallu , Bhateria, Manisha , Bhatta, R S . (2557). In-vitro evaluation of Bacopa monniera extract and individual constituents on human recombinant Monoamine oxidase enzymes.
    : Central Drug Research Institute (CDRI), India.
Singh, Rajbir , Ramakrishna, Rachumallu , Bhateria, Manisha , Bhatta, R S . 2557. "In-vitro evaluation of Bacopa monniera extract and individual constituents on human recombinant Monoamine oxidase enzymes".
    : Central Drug Research Institute (CDRI), India.
Singh, Rajbir , Ramakrishna, Rachumallu , Bhateria, Manisha , Bhatta, R S . "In-vitro evaluation of Bacopa monniera extract and individual constituents on human recombinant Monoamine oxidase enzymes."
    : Central Drug Research Institute (CDRI), India, 2557. Print.
Singh, Rajbir , Ramakrishna, Rachumallu , Bhateria, Manisha , Bhatta, R S . In-vitro evaluation of Bacopa monniera extract and individual constituents on human recombinant Monoamine oxidase enzymes. : Central Drug Research Institute (CDRI), India; 2557.