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Stereoselective synthesis of tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues by ‘click’ chemistry and investigation of their biological activity

หน่วยงาน Central Drug Research Institute (CDRI), India

รายละเอียด

ชื่อเรื่อง : Stereoselective synthesis of tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues by ‘click’ chemistry and investigation of their biological activity
นักวิจัย : Reddy, P V , Saquib, Mohammad , Mishra, N N , Shukla, P K , Shaw, A K
คำค้น : THF alkynes , THF azides , C-nucleosides , ‘click’ chemistry , 1,2,3-triazoles
หน่วยงาน : Central Drug Research Institute (CDRI), India
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Arkivoc, 2014, 2014 (iv), 170-182 , http://hdl.handle.net/123456789/1421
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CSIR-CDRI Communication No. 8564
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The construction of a novel series of enantiopure tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues utilizing click reaction of sugar derived tetrahydrofuranyl alkynes with various ‘in house’ synthesized sugar derived tetrahydrofuranyl azides and an adamantyl azide is described. The biological significance of the synthesized C-nucleosides was highlighted by evaluating them in vitro for anti-bacterial and anti-fungal activity wherein a number of compounds were found to show excellent anti-bacterial activity and moderate anti-fungal activity.

บรรณานุกรม :
Reddy, P V , Saquib, Mohammad , Mishra, N N , Shukla, P K , Shaw, A K . (2557). Stereoselective synthesis of tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues by ‘click’ chemistry and investigation of their biological activity.
    : Central Drug Research Institute (CDRI), India.
Reddy, P V , Saquib, Mohammad , Mishra, N N , Shukla, P K , Shaw, A K . 2557. "Stereoselective synthesis of tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues by ‘click’ chemistry and investigation of their biological activity".
    : Central Drug Research Institute (CDRI), India.
Reddy, P V , Saquib, Mohammad , Mishra, N N , Shukla, P K , Shaw, A K . "Stereoselective synthesis of tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues by ‘click’ chemistry and investigation of their biological activity."
    : Central Drug Research Institute (CDRI), India, 2557. Print.
Reddy, P V , Saquib, Mohammad , Mishra, N N , Shukla, P K , Shaw, A K . Stereoselective synthesis of tetrahydrofuranyl 1,2,3-triazolyl C-nucleoside analogues by ‘click’ chemistry and investigation of their biological activity. : Central Drug Research Institute (CDRI), India; 2557.