| ชื่อเรื่อง | : | Synthesis of Biologically Active Pyridoimidazole/Imidazobenzothiazole Annulated Polyheterocycles using Cyanuric Chloride in water |
| นักวิจัย | : | Pandey, A K , Sharma, Rashmi , Singh, Awantika , Shukla, Sanjeev , Srivastava, Kumkum , Puri, S K , Kumar, Brijesh , Chauhan, P M S |
| คำค้น | : | Cyanuric Chloride , Heterocycles , Imidazobenzothiazole , Pictet-Spengler Reaction , Pyridoimidazole , Tetra-N-Butylammonium Bromide (TBAB) |
| หน่วยงาน | : | Central Drug Research Institute (CDRI), India |
| ผู้ร่วมงาน | : | - |
| ปีพิมพ์ | : | 2557 |
| อ้างอิง | : | RSC Advances, 2014, 4, 26757-26770 , http://hdl.handle.net/123456789/1410 |
| ที่มา | : | - |
| ความเชี่ยวชาญ | : | - |
| ความสัมพันธ์ | : | CSIR-CDRI Communication No. 8715 |
| ขอบเขตของเนื้อหา | : | - |
| บทคัดย่อ/คำอธิบาย | : | An efficient and mild protocol for rapid access to N-fused polyheterocycles via Pictet-Spengler type 6-endo cyclization using cyanuric chloride in aqueous reaction medium has been developed. The protocol is successfully applied to a wide range of aryl/heteroaryl aldehydes (8a-o), ketones (10a-e), electron rich metallocene aldehyde (8e) and indoline-2,3-diones (12a-c) using cyanuric chloride (15-20 mol %) with tetra-n-butylammonium bromide (TBAB) (2.0 equiv.) as an additive at 80-90 ˚C to give polyheterocycles in good to excellent yield (66-92%). Moreover some of the synthesized compounds were found to exhibit antiplasmodial activity against chloroquine sensitive (CQ-S) 3D7 and chloroquine resistant (CQ-R) K1 strains of Plasmodium falciparum. |
| บรรณานุกรม | : |
Pandey, A K , Sharma, Rashmi , Singh, Awantika , Shukla, Sanjeev , Srivastava, Kumkum , Puri, S K , Kumar, Brijesh , Chauhan, P M S . (2557). Synthesis of Biologically Active Pyridoimidazole/Imidazobenzothiazole Annulated Polyheterocycles using Cyanuric Chloride in water.
: Central Drug Research Institute (CDRI), India. Pandey, A K , Sharma, Rashmi , Singh, Awantika , Shukla, Sanjeev , Srivastava, Kumkum , Puri, S K , Kumar, Brijesh , Chauhan, P M S . 2557. "Synthesis of Biologically Active Pyridoimidazole/Imidazobenzothiazole Annulated Polyheterocycles using Cyanuric Chloride in water".
: Central Drug Research Institute (CDRI), India. Pandey, A K , Sharma, Rashmi , Singh, Awantika , Shukla, Sanjeev , Srivastava, Kumkum , Puri, S K , Kumar, Brijesh , Chauhan, P M S . "Synthesis of Biologically Active Pyridoimidazole/Imidazobenzothiazole Annulated Polyheterocycles using Cyanuric Chloride in water."
: Central Drug Research Institute (CDRI), India, 2557. Print. Pandey, A K , Sharma, Rashmi , Singh, Awantika , Shukla, Sanjeev , Srivastava, Kumkum , Puri, S K , Kumar, Brijesh , Chauhan, P M S . Synthesis of Biologically Active Pyridoimidazole/Imidazobenzothiazole Annulated Polyheterocycles using Cyanuric Chloride in water. : Central Drug Research Institute (CDRI), India; 2557.
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