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Synthesis of Biologically Active Pyridoimidazole/Imidazobenzothiazole Annulated Polyheterocycles using Cyanuric Chloride in water

หน่วยงาน Central Drug Research Institute (CDRI), India

รายละเอียด

ชื่อเรื่อง : Synthesis of Biologically Active Pyridoimidazole/Imidazobenzothiazole Annulated Polyheterocycles using Cyanuric Chloride in water
นักวิจัย : Pandey, A K , Sharma, Rashmi , Singh, Awantika , Shukla, Sanjeev , Srivastava, Kumkum , Puri, S K , Kumar, Brijesh , Chauhan, P M S
คำค้น : Cyanuric Chloride , Heterocycles , Imidazobenzothiazole , Pictet-Spengler Reaction , Pyridoimidazole , Tetra-N-Butylammonium Bromide (TBAB)
หน่วยงาน : Central Drug Research Institute (CDRI), India
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : RSC Advances, 2014, 4, 26757-26770 , http://hdl.handle.net/123456789/1410
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CSIR-CDRI Communication No. 8715
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

An efficient and mild protocol for rapid access to N-fused polyheterocycles via Pictet-Spengler type 6-endo cyclization using cyanuric chloride in aqueous reaction medium has been developed. The protocol is successfully applied to a wide range of aryl/heteroaryl aldehydes (8a-o), ketones (10a-e), electron rich metallocene aldehyde (8e) and indoline-2,3-diones (12a-c) using cyanuric chloride (15-20 mol %) with tetra-n-butylammonium bromide (TBAB) (2.0 equiv.) as an additive at 80-90 ˚C to give polyheterocycles in good to excellent yield (66-92%). Moreover some of the synthesized compounds were found to exhibit antiplasmodial activity against chloroquine sensitive (CQ-S) 3D7 and chloroquine resistant (CQ-R) K1 strains of Plasmodium falciparum.

บรรณานุกรม :
Pandey, A K , Sharma, Rashmi , Singh, Awantika , Shukla, Sanjeev , Srivastava, Kumkum , Puri, S K , Kumar, Brijesh , Chauhan, P M S . (2557). Synthesis of Biologically Active Pyridoimidazole/Imidazobenzothiazole Annulated Polyheterocycles using Cyanuric Chloride in water.
    : Central Drug Research Institute (CDRI), India.
Pandey, A K , Sharma, Rashmi , Singh, Awantika , Shukla, Sanjeev , Srivastava, Kumkum , Puri, S K , Kumar, Brijesh , Chauhan, P M S . 2557. "Synthesis of Biologically Active Pyridoimidazole/Imidazobenzothiazole Annulated Polyheterocycles using Cyanuric Chloride in water".
    : Central Drug Research Institute (CDRI), India.
Pandey, A K , Sharma, Rashmi , Singh, Awantika , Shukla, Sanjeev , Srivastava, Kumkum , Puri, S K , Kumar, Brijesh , Chauhan, P M S . "Synthesis of Biologically Active Pyridoimidazole/Imidazobenzothiazole Annulated Polyheterocycles using Cyanuric Chloride in water."
    : Central Drug Research Institute (CDRI), India, 2557. Print.
Pandey, A K , Sharma, Rashmi , Singh, Awantika , Shukla, Sanjeev , Srivastava, Kumkum , Puri, S K , Kumar, Brijesh , Chauhan, P M S . Synthesis of Biologically Active Pyridoimidazole/Imidazobenzothiazole Annulated Polyheterocycles using Cyanuric Chloride in water. : Central Drug Research Institute (CDRI), India; 2557.