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Expedient Base-Mediated Desulfitative Dimethylamination, Oxidation, or Etherification of 2-(Methylsulfanyl)-3,5-dihydro-4H-imidazol-4-one Scaffolds

หน่วยงาน Central Drug Research Institute (CDRI), India

รายละเอียด

ชื่อเรื่อง : Expedient Base-Mediated Desulfitative Dimethylamination, Oxidation, or Etherification of 2-(Methylsulfanyl)-3,5-dihydro-4H-imidazol-4-one Scaffolds
นักวิจัย : Khan, Shahnawaz , Tyagi, Vikas , Mahar, Rohit , Bajpai, Vikas , Kumar, Brijesh , Chauhan, P M S
คำค้น : Heterocycles , Aminations , Etherifications , Oxidations , Ketones , Amines , Ethers
หน่วยงาน : Central Drug Research Institute (CDRI), India
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : Synthesis, 2013, 45(17), 2405-2412 , http://hdl.handle.net/123456789/1403
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CSIR-CDRI Communication No. 8441
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The dimethylamino functionality is generally introduced onto the 3,5-dihydro-4H-imidazol-4-one skeleton by treatment of a halogenated derivative with low-boiling dimethylamine at a high temperature and pressure. The corresponding aliphatic ethers are usually prepared by Williamson ether synthesis, but the available transition-metal-catalyzed methods require highly toxic reagents (such as dimethyl sulfate or methyl halides) and expensive metal catalysts, and they entail harsh reaction conditions and complex workups. A simple and efficient method is described for base-mediated¬ desulfitative dimethylamination, oxidation, or etherification at the C2-position of the 2-(methylsulfanyl)-3,5-dihydro-4H-imidazol-4-one scaffold by using potassium carbonate and aqueous N,N-dimethylformamide or an aliphatic alcohol.

บรรณานุกรม :
Khan, Shahnawaz , Tyagi, Vikas , Mahar, Rohit , Bajpai, Vikas , Kumar, Brijesh , Chauhan, P M S . (2556). Expedient Base-Mediated Desulfitative Dimethylamination, Oxidation, or Etherification of 2-(Methylsulfanyl)-3,5-dihydro-4H-imidazol-4-one Scaffolds.
    : Central Drug Research Institute (CDRI), India.
Khan, Shahnawaz , Tyagi, Vikas , Mahar, Rohit , Bajpai, Vikas , Kumar, Brijesh , Chauhan, P M S . 2556. "Expedient Base-Mediated Desulfitative Dimethylamination, Oxidation, or Etherification of 2-(Methylsulfanyl)-3,5-dihydro-4H-imidazol-4-one Scaffolds".
    : Central Drug Research Institute (CDRI), India.
Khan, Shahnawaz , Tyagi, Vikas , Mahar, Rohit , Bajpai, Vikas , Kumar, Brijesh , Chauhan, P M S . "Expedient Base-Mediated Desulfitative Dimethylamination, Oxidation, or Etherification of 2-(Methylsulfanyl)-3,5-dihydro-4H-imidazol-4-one Scaffolds."
    : Central Drug Research Institute (CDRI), India, 2556. Print.
Khan, Shahnawaz , Tyagi, Vikas , Mahar, Rohit , Bajpai, Vikas , Kumar, Brijesh , Chauhan, P M S . Expedient Base-Mediated Desulfitative Dimethylamination, Oxidation, or Etherification of 2-(Methylsulfanyl)-3,5-dihydro-4H-imidazol-4-one Scaffolds. : Central Drug Research Institute (CDRI), India; 2556.