ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

Folded conformations due to arene interactions in dissymmetrical and symmetrical butylidene linker models based on pyrazolo[3,4-d]pyrimidine, purine and 7-deazapurine

หน่วยงาน Central Drug Research Institute (CDRI), India

รายละเอียด

ชื่อเรื่อง : Folded conformations due to arene interactions in dissymmetrical and symmetrical butylidene linker models based on pyrazolo[3,4-d]pyrimidine, purine and 7-deazapurine
นักวิจัย : Avasthi, Kamlakar , Shukla, Lakshmi , Kant, Ruchir , Ravikumar, Krishnan
คำค้น : Arene Interactions , Butylidene Linker , Propylene Linker , Purine , 7-Deazapurine , Pyrazolo[3,4-D]Pyrimidine
หน่วยงาน : Central Drug Research Institute (CDRI), India
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Acta Crystallographica Section C Structural Chemistry 2014, 70(6), 555-61 , http://hdl.handle.net/123456789/1369
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CSIR-CDRI communication No. 8673
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Abstract Butylidene linker models 1-(2-(2,6-dimethylsulfanyl-9H-purin-9-yl)-2-methylenepropane-4,6-dimethylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidine, (XI), C18H20N8S4, 7,7′-(2-methylenepropane-1,3-diyl)bis(3-methyl-2-methylsulfanyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one), (XIV), C20H22N6O2S2 and 7-(2-(4,6-dimethylsulfanyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2-methylenepropane-3-methyl-2-methylsulfanyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one, (XV), C19H21N7OS3 show folded conformations in solution as shown by proton NMR analysis. This folding carries over to solid state for all models as revealed by X-ray crystallography due to intramolecular π‒π interactions. Whereas, only one model (XIV) shows additional intramolecular C‒H…π interactions in solid state. To the best of our knowledge, this is the first report using pyrrolo[2,3-d]pyrimidine nucleus for such kind of study. In addition to the π‒π interactions, crystal structures are also stabilized by other weak intermolecular C‒H…S/N/O and/or S…N/S interactions.

บรรณานุกรม :
Avasthi, Kamlakar , Shukla, Lakshmi , Kant, Ruchir , Ravikumar, Krishnan . (2557). Folded conformations due to arene interactions in dissymmetrical and symmetrical butylidene linker models based on pyrazolo[3,4-d]pyrimidine, purine and 7-deazapurine.
    : Central Drug Research Institute (CDRI), India.
Avasthi, Kamlakar , Shukla, Lakshmi , Kant, Ruchir , Ravikumar, Krishnan . 2557. "Folded conformations due to arene interactions in dissymmetrical and symmetrical butylidene linker models based on pyrazolo[3,4-d]pyrimidine, purine and 7-deazapurine".
    : Central Drug Research Institute (CDRI), India.
Avasthi, Kamlakar , Shukla, Lakshmi , Kant, Ruchir , Ravikumar, Krishnan . "Folded conformations due to arene interactions in dissymmetrical and symmetrical butylidene linker models based on pyrazolo[3,4-d]pyrimidine, purine and 7-deazapurine."
    : Central Drug Research Institute (CDRI), India, 2557. Print.
Avasthi, Kamlakar , Shukla, Lakshmi , Kant, Ruchir , Ravikumar, Krishnan . Folded conformations due to arene interactions in dissymmetrical and symmetrical butylidene linker models based on pyrazolo[3,4-d]pyrimidine, purine and 7-deazapurine. : Central Drug Research Institute (CDRI), India; 2557.