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Metal-Free Tandem Approach to Structurally Diverse N-Heterocycles: Synthesis of 1,2,4-Oxadiazoles and Pyrimidinones

หน่วยงาน Central Drug Research Institute (CDRI), India

รายละเอียด

ชื่อเรื่อง : Metal-Free Tandem Approach to Structurally Diverse N-Heterocycles: Synthesis of 1,2,4-Oxadiazoles and Pyrimidinones
นักวิจัย : Gupta, P K , Hussain, M K , Asad, Mohd. , Kant, Ruchir , Mahar, Rohit , Shukla, S K , Hajela, Kanchan
คำค้น : N-Heterocycles , Oxadiazoles , Pyrimidinones
หน่วยงาน : Central Drug Research Institute (CDRI), India
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : New Journal of Chemistry, 2014, 38(7) 3062-3070 , http://hdl.handle.net/123456789/1366
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CSIR-CDRI Communication No. 8671
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

A metal-free one-pot approach to the diversity oriented synthesis of N-heterocycles, 1,2,4-oxadiazoles and 2,6 disubstituted pyrimidin-4-ones is described via carboxamidation of amidines with aryl carboxylic acids and aryl propargylic acids. The reactions occur at room temperature forming N-acylamidines which undergo tandem nucleophilic addition / deamination / intramolecular cyclisation to give the corresponding heterocyclic compounds in good to excellent yields. This one pot approach has led to the successful synthesis of drug lead molecule, ataluren, (3-(5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl) benzoic acid in two steps.

บรรณานุกรม :
Gupta, P K , Hussain, M K , Asad, Mohd. , Kant, Ruchir , Mahar, Rohit , Shukla, S K , Hajela, Kanchan . (2557). Metal-Free Tandem Approach to Structurally Diverse N-Heterocycles: Synthesis of 1,2,4-Oxadiazoles and Pyrimidinones.
    : Central Drug Research Institute (CDRI), India.
Gupta, P K , Hussain, M K , Asad, Mohd. , Kant, Ruchir , Mahar, Rohit , Shukla, S K , Hajela, Kanchan . 2557. "Metal-Free Tandem Approach to Structurally Diverse N-Heterocycles: Synthesis of 1,2,4-Oxadiazoles and Pyrimidinones".
    : Central Drug Research Institute (CDRI), India.
Gupta, P K , Hussain, M K , Asad, Mohd. , Kant, Ruchir , Mahar, Rohit , Shukla, S K , Hajela, Kanchan . "Metal-Free Tandem Approach to Structurally Diverse N-Heterocycles: Synthesis of 1,2,4-Oxadiazoles and Pyrimidinones."
    : Central Drug Research Institute (CDRI), India, 2557. Print.
Gupta, P K , Hussain, M K , Asad, Mohd. , Kant, Ruchir , Mahar, Rohit , Shukla, S K , Hajela, Kanchan . Metal-Free Tandem Approach to Structurally Diverse N-Heterocycles: Synthesis of 1,2,4-Oxadiazoles and Pyrimidinones. : Central Drug Research Institute (CDRI), India; 2557.