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Ventromedial prefrontal cortex stimulation enhances memory and hippocampal neurogenesis in the middle-aged rats

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Ventromedial prefrontal cortex stimulation enhances memory and hippocampal neurogenesis in the middle-aged rats
นักวิจัย : Liu, Albert , Jain, Neeraj , Vyas, Ajai , Lim, Lee Wei
คำค้น : DRNTU::Science::Biological sciences::Zoology::Anatomy
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2558
อ้างอิง : Liu, A., Jain, N., Vyas, A., & Lim, L. W. (2015). Ventromedial prefrontal cortex stimulation enhances memory and hippocampal neurogenesis in the middle-aged rats. eLife, in press. , 2050-084X , http://hdl.handle.net/10220/25314 , http://dx.doi.org/10.7554/eLife.04803
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : eLife
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Memory dysfunction is a key symptom of age-related dementia. Although recent studies have suggested positive effects of electrical stimulation for memory enhancement, its potential targets remain largely unknown. In this study, we hypothesized that spatially targeted deep brain stimulation of ventromedial prefrontal cortex enhanced memory functions in a middle-aged rat model. Our results show that acute stimulation enhanced the short-, but not the long-term memory in the novel-object recognition task. Interestingly, after chronic high-frequency stimulation, both the short- and long-term memories were robustly improved in the novel-object recognition test and Morris water-maze spatial task compared to sham. Our results also demonstrated that chronic ventromedial prefrontal cortex high-frequency stimulation upregulated neurogenesis-associated genes along with enhanced hippocampal cell proliferation. Importantly, these memory behaviors were strongly correlated with the hippocampal neurogenesis. Overall, these findings suggest that chronic ventromedial prefrontal cortex high-frequency stimulation may serve as a novel effective therapeutic target for dementia-related disorders.

บรรณานุกรม :
Liu, Albert , Jain, Neeraj , Vyas, Ajai , Lim, Lee Wei . (2558). Ventromedial prefrontal cortex stimulation enhances memory and hippocampal neurogenesis in the middle-aged rats.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Liu, Albert , Jain, Neeraj , Vyas, Ajai , Lim, Lee Wei . 2558. "Ventromedial prefrontal cortex stimulation enhances memory and hippocampal neurogenesis in the middle-aged rats".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Liu, Albert , Jain, Neeraj , Vyas, Ajai , Lim, Lee Wei . "Ventromedial prefrontal cortex stimulation enhances memory and hippocampal neurogenesis in the middle-aged rats."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2558. Print.
Liu, Albert , Jain, Neeraj , Vyas, Ajai , Lim, Lee Wei . Ventromedial prefrontal cortex stimulation enhances memory and hippocampal neurogenesis in the middle-aged rats. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2558.