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Expression and function of toll-like receptors on dendritic cells and other antigen presenting cells from non-human primates

หน่วยงาน จุฬาลงกรณ์มหาวิทยาลัย

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ชื่อเรื่อง : Expression and function of toll-like receptors on dendritic cells and other antigen presenting cells from non-human primates
นักวิจัย : Chutitorn Ketloy
คำค้น : Antigen presenting cells , Dendritic cells , Cell receptors , Toll-Like Receptors , Immunological adjuvants
หน่วยงาน : จุฬาลงกรณ์มหาวิทยาลัย
ผู้ร่วมงาน : Kiat Ruxrungtham , Sathit Pichyangkul , Chulalongkorn University. Graduate School
ปีพิมพ์ : 2550
อ้างอิง : http://cuir.car.chula.ac.th/handle/123456789/13110
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
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Thesis (Ph.D.)--Chulalongkorn University, 2007

Antigen presenting cells (APCs), especially dendritic cells (DCs), play a crucial role in immune responses against infections by sensing microbial invasion through toll-like receptors (TLRs). Thus, TLR ligands are attractive candidates for use in humans and animal models as vaccine adjuvants. So far, no studies have performed on TLR expression in non-human primates such as rhesus macaques. We therefore performed a comparative cross-species study on TLR expression patterns (TLR3, 4, 7, 8 and 9) of APCs in human, rhesus macaques and mice. We demonstrate that blood DC subsets of rhesus macaque expressed the same sets of TLRs as human DCs but substantially differed from mouse DC subsets. In macaque and human, myeloid DCs (MDCs) expressed TLR3, 4, 7 and 8 whereas plasmacytoid DCs (PDCs) expressed only TLR7 and 9, in contrast to mouse, both DC subsets expressed all TLRs (TLR3, 4, 7, 8 and 9). Additionally, TLR expression patterns in macaque monocyte-derived dendritic cells (mo-DCs) (i.e., TLR3, 4 and 8), monocytes (i.e., TLR4, 7, and 8) and B cells (i.e., TLR4, 7, 8, and 9) were also similar to their human counterparts. However, the responsiveness of macaque APCs to certain TLR ligands partially differed from those of human in terms of phenotype differentiation and cytokine production. Strikingly, in contrast to human mo-DCs, no IL-12p70 production was observed when macaque mo-DCs were stimulated with TLR ligands. Our results provide important information for a rational design of animal models in evaluating TLR ligands as adjuvant in vivo.

บรรณานุกรม :
Chutitorn Ketloy . (2550). Expression and function of toll-like receptors on dendritic cells and other antigen presenting cells from non-human primates.
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย.
Chutitorn Ketloy . 2550. "Expression and function of toll-like receptors on dendritic cells and other antigen presenting cells from non-human primates".
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย.
Chutitorn Ketloy . "Expression and function of toll-like receptors on dendritic cells and other antigen presenting cells from non-human primates."
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย, 2550. Print.
Chutitorn Ketloy . Expression and function of toll-like receptors on dendritic cells and other antigen presenting cells from non-human primates. กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย; 2550.