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Effects of Malvastrum coromadelianum Linn. extract on second degree burn wound healing in diabetic and non-diabetic rats

หน่วยงาน จุฬาลงกรณ์มหาวิทยาลัย

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ชื่อเรื่อง : Effects of Malvastrum coromadelianum Linn. extract on second degree burn wound healing in diabetic and non-diabetic rats
นักวิจัย : Kantarote Sookkul
คำค้น : Wound healing , Burns and scalds
หน่วยงาน : จุฬาลงกรณ์มหาวิทยาลัย
ผู้ร่วมงาน : Boonyong Tantisira , Mayuree Tantisira , Juraiporn Somboonwong , Chulalongkorn University. Graduate School
ปีพิมพ์ : 2549
อ้างอิง : http://cuir.car.chula.ac.th/handle/123456789/8532
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Thesis (M.Sc.)--Chulalongkorn University, 2006

The present study aimed to investigate the healing effect of aqueous extract of Malvastrum coromandelianum (MC) Linn. Extract on second degree bum wound, generated by 10 second-application of 90 degree celsius hot plate on the selected area of the back of non-diabetic and diabetic rats. Male Wistar rats weighting 250-300 g were used and diabetes was induced by a single injection of streptozotocin in the dose of 60 mg/kg B.W. intravenously into tail vein. Evaluation of wound healing by an estimation of degree of wound healing, measurement of cutaneous blood flow by Laser Doppler Flowmeter, analysis of malondialdehyde (MDA) as indicator of oxidative stress and histological observation were made at day 3, 7 and 14 posts burning. The results revealed that degree of wound contraction in both diabetic and non-diabetic rats treated with MC extract was significantly different from those observed in their respective untreated and NSS-treated groups at day 3, 7 and 14 posts burning. In comparison to their respective control groups, tissue blood flow was significantly increased in MC extract-treated group at all three time points in diabetic rats whereas it was observed only at day 3 and 7 in non-diabetic group.On day 14, histological observation demonstrated a complete re-epithelialization resulting in complete closure of the wound in non-diabetic rats receiving MC extract while epithelialization in MC extract-treated diabetes rats, though better than its control groups, still incomplete. Application of MC extract seemed to reduce the migration of neutrophils in diabetic and non-diabetic rats though with a lesser extent in the former group. In non-diabetic, burn injury significantly increased oxidative stress which was counteracted by MC extract day 3 and 7. However, in diabetic rats antioxidant property of MC was evident only at day 14. In conclusion, the present studies have demonstrated the wound healing effect of the aqueous extract of Malvastrum coromandelianum Linn. On burn wound in diabetic as well as non-diabetic rats. Slower rate of healing was noticed in diabetic rats. An increase of cutaneous boold flow, anti-oxidation property as well as inhibition of the inflammation process in likely top explain, at least, in part, the beneficial effect observed.

บรรณานุกรม :
Kantarote Sookkul . (2549). Effects of Malvastrum coromadelianum Linn. extract on second degree burn wound healing in diabetic and non-diabetic rats.
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย.
Kantarote Sookkul . 2549. "Effects of Malvastrum coromadelianum Linn. extract on second degree burn wound healing in diabetic and non-diabetic rats".
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย.
Kantarote Sookkul . "Effects of Malvastrum coromadelianum Linn. extract on second degree burn wound healing in diabetic and non-diabetic rats."
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย, 2549. Print.
Kantarote Sookkul . Effects of Malvastrum coromadelianum Linn. extract on second degree burn wound healing in diabetic and non-diabetic rats. กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย; 2549.