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Antidiabetic Effects And Mechanisms Of Action Of p-Methoxycinnamic Acid

หน่วยงาน จุฬาลงกรณ์มหาวิทยาลัย

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ชื่อเรื่อง : Antidiabetic Effects And Mechanisms Of Action Of p-Methoxycinnamic Acid
นักวิจัย : Sirichai Adisakwattana
คำค้น : Hypoglycemic agents , Insulin
หน่วยงาน : จุฬาลงกรณ์มหาวิทยาลัย
ผู้ร่วมงาน : Sophon Roengsumran , Sirintorn Yibchok-anun , Chulalongkorn University. Graduate School
ปีพิมพ์ : 2548
อ้างอิง : 9745325406 , http://cuir.car.chula.ac.th/handle/123456789/8437
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Thesis (Ph.D.)--Chulalongkorn University, 2005

p-MCA decreased fasting plasma glucose and increased insulin concentrations in both normal and diabetic rats. In addition, it improved also glucose intolerance in diabetic rats. During 4 weeks of the study. P-MCA reduced plasma glucose concentration in diabetic rats but not in normal rats. p-MCA reduced the excessive activities of hepatic glucose-6-phosphatase, and increased hepatic hexokinase, glucokinase, phosphofructokinase, hepatic glycogen in diabetic rats. p-MCA increased insulin secretion from the perfused rat pancreas and INS-1 cells in a concentration-dependent manner. In addition, p-MCA increased intracellular Ca[superscript2]+ concentration ([Ca[superscript2]+]) in INS-1 cells. The p-MCA-induced insulin secretion and rise in [Ca[superscript2]+] were markedly inhibited in the absence of extracellular Ca[superscript2]+ or in the presence of an L-type Ca[superscript2]+ channel blocker nimodipine. Diazoxide, and ATP-sensitive K+ channel opener, did not alter p-MCA-induced insulin secretion, nor [Ca[superscript2]+] response. These results suggested that p-MCA increased Ca[superscript2]+ influx via the L-type Ca[superscript2]+ channels, but not through the closure of ATP-sensitive K+ channels In addition, p-MCA enhanced glucose- and glyburide-induced insulin secretion and it also the increase in insulin secretion and a rise of [Ca[superscript2]+] induced by KCI-and Bay K 8644, an L-type Ca2+ channel. Furthermore, p-MCA increased cyclic AMP content of INS-1 cells and enhanced the increase of cyclic AMP content induced by forskolin ; however p-MCA failed to enhance the effect of a phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine. P-MCA was a potent competitive inhibitor against yeast alpha-glucosidase However, it had no inhibitory activities on mammalian alpha-glucosidases and alpha-amylase.

บรรณานุกรม :
Sirichai Adisakwattana . (2548). Antidiabetic Effects And Mechanisms Of Action Of p-Methoxycinnamic Acid.
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย.
Sirichai Adisakwattana . 2548. "Antidiabetic Effects And Mechanisms Of Action Of p-Methoxycinnamic Acid".
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย.
Sirichai Adisakwattana . "Antidiabetic Effects And Mechanisms Of Action Of p-Methoxycinnamic Acid."
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย, 2548. Print.
Sirichai Adisakwattana . Antidiabetic Effects And Mechanisms Of Action Of p-Methoxycinnamic Acid. กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย; 2548.