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Protein extract from fruit pulp of Siamese momordica charantia with insulin secretagogue and insulin-like activities

หน่วยงาน จุฬาลงกรณ์มหาวิทยาลัย

รายละเอียด

ชื่อเรื่อง : Protein extract from fruit pulp of Siamese momordica charantia with insulin secretagogue and insulin-like activities
นักวิจัย : Sirintorn Yibchok-anun , Sophon Roengsumran , H. Hsu, Walter
คำค้น : Plant proteins , Momordica charantia , Insulin
หน่วยงาน : จุฬาลงกรณ์มหาวิทยาลัย
ผู้ร่วมงาน : Chulalongkorn University. Faculty of Veterinary Science , Chulalongkorn University. Faculty of Science , Iowa State University. College of Veterinary Medicine
ปีพิมพ์ : 2547
อ้างอิง : http://cuir.car.chula.ac.th/handle/123456789/6151
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The aim of this study was to investigate the effects of zinc-free protein extract from bitter gourd fruit pulp on plasma glucose concentration and insulin responses in normal and STZ-induced diabetic rats. Furthermore, we investigated the direct effect of the MC protein extract on insulin and glucagons secretions from the perfused rat pancreas as well as glucose uptake in C2C12 rat myocytes and 3T3-L1 rat adipocytes. The protein from Thai bitter gourd (Momordica charantia) fruit pulp was extracted and studied for its hypoglycemic effect. Subcutaneous administration of the protein extract (5 and 10 mg/kg) significantly and markedly decreased plasma glucose concentrations in both normal and streptozotocin-induced diabetic rats in a dose-dependent manner. The onset of the protein extract-induced antihyperglycemia/hypoglycemia was observed at 4 and 6 h in diabetic and normal rats, respectively. This protein extract also raised plasma insulin concentrations by 2 fold 4 h following subcutaneous administration. In perfused rat pancreas, the protein extract (10 [M]g/ml) increased insulin secretion, but not glucagons secretion, which was apparent within 5 min of administration and was persistent during 30 min of administration. Furthermore, the protein extract enhanced glucose uptake into C2C12 myocytes and 3T3-L1 adipocytes. Thus, the M. charantia protein has both insulin secretagogue and insulin-like activities that could help explain its hypoglycemic effect in vivo.

บรรณานุกรม :
Sirintorn Yibchok-anun , Sophon Roengsumran , H. Hsu, Walter . (2547). Protein extract from fruit pulp of Siamese momordica charantia with insulin secretagogue and insulin-like activities.
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย.
Sirintorn Yibchok-anun , Sophon Roengsumran , H. Hsu, Walter . 2547. "Protein extract from fruit pulp of Siamese momordica charantia with insulin secretagogue and insulin-like activities".
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย.
Sirintorn Yibchok-anun , Sophon Roengsumran , H. Hsu, Walter . "Protein extract from fruit pulp of Siamese momordica charantia with insulin secretagogue and insulin-like activities."
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย, 2547. Print.
Sirintorn Yibchok-anun , Sophon Roengsumran , H. Hsu, Walter . Protein extract from fruit pulp of Siamese momordica charantia with insulin secretagogue and insulin-like activities. กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย; 2547.