ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

Manipulating galectin expression in zebrafish (Danio rerio)

หน่วยงาน National Institute Of Oceanography (NIO), India

รายละเอียด

ชื่อเรื่อง : Manipulating galectin expression in zebrafish (Danio rerio)
นักวิจัย : Feng, C. , Nita-Lazar, M. , Gonzalez-Montalban, N. , Wang, J. , Mancini, J. , Ravindran, C. , Ahmed, H. , Vasta, G.R.
คำค้น : gene expression , public health , diseases , Danio rerio
หน่วยงาน : National Institute Of Oceanography (NIO), India
ผู้ร่วมงาน : -
ปีพิมพ์ : 2558
อ้างอิง : Galectins:Methods and protocols. ed. by: Stowell, S.R.; Cummings, R.D.. Springer; New York; USA; 2015; 327-341 , http://drs.nio.org/drs/handle/2264/4679
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Methods in molecular biology: Methods and protocols; 1207; Walker, J.M.; ed.
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Techniques for disrupting gene expression are invaluable tools for the analysis of the biological role(s) of a gene product. Because of its genetic tractability and multiple advantages over conventional mammalian models, the zebrafish (Danio rerio) is recognized as a powerful system for gaining new insight into diverse aspects of human health and disease. Among the multiple mammalian gene families for which the zebrafish has shown promise as an invaluable model for functional studies, the galectins have attracted great interest due to their participation in early development, regulation of immune homeostasis, and recognition of microbial pathogens. Galectins are Beta-galactosyl-binding lectins with a characteristic sequence motif in their carbohydrate recognition domains (CRDs), which comprise an evolutionary conserved family ubiquitous in eukaryotic taxa. Galectins are emerging as key players in the modulation of many important pathological processes, which include acute and chronic inflammatory diseases, autoimmunity and cancer, thus making them potential molecular targets for innovative drug discovery. Here, we provide a review of the current methods available for the manipulation of gene expression in the zebrafish, with a focus on gene knockdown [morpholino (MO)-derived antisense oligonucleotides] and knockout (CRISPR-Cas) technologies.

บรรณานุกรม :
Feng, C. , Nita-Lazar, M. , Gonzalez-Montalban, N. , Wang, J. , Mancini, J. , Ravindran, C. , Ahmed, H. , Vasta, G.R. . (2558). Manipulating galectin expression in zebrafish (Danio rerio).
    : National Institute Of Oceanography (NIO), India.
Feng, C. , Nita-Lazar, M. , Gonzalez-Montalban, N. , Wang, J. , Mancini, J. , Ravindran, C. , Ahmed, H. , Vasta, G.R. . 2558. "Manipulating galectin expression in zebrafish (Danio rerio)".
    : National Institute Of Oceanography (NIO), India.
Feng, C. , Nita-Lazar, M. , Gonzalez-Montalban, N. , Wang, J. , Mancini, J. , Ravindran, C. , Ahmed, H. , Vasta, G.R. . "Manipulating galectin expression in zebrafish (Danio rerio)."
    : National Institute Of Oceanography (NIO), India, 2558. Print.
Feng, C. , Nita-Lazar, M. , Gonzalez-Montalban, N. , Wang, J. , Mancini, J. , Ravindran, C. , Ahmed, H. , Vasta, G.R. . Manipulating galectin expression in zebrafish (Danio rerio). : National Institute Of Oceanography (NIO), India; 2558.