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Effect of processing and formulation variables on the release Diclofenac Sodium from Microtablets

หน่วยงาน จุฬาลงกรณ์มหาวิทยาลัย

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ชื่อเรื่อง : Effect of processing and formulation variables on the release Diclofenac Sodium from Microtablets
นักวิจัย : Surawee Chantorn
คำค้น : Diclopenac Sodium , Ethylcellulose , Hydroxypropyl methylcellulose
หน่วยงาน : จุฬาลงกรณ์มหาวิทยาลัย
ผู้ร่วมงาน : Garnpimol C. Ritthidej , Chairote Kunpanitchakit , Chulalongkorn University. Faculty of Pharmaceutical Sciences
ปีพิมพ์ : 2546
อ้างอิง : 9741750145 , http://cuir.car.chula.ac.th/handle/123456789/2058
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Thesis (M.Sc. in Pharm)--Chulalongkorn University, 2003

The effect of processing and formulation parameters on properties and drug release of microtablets as subunit in multiparticulate dosage form was investigated in this study. In addition, a sustained release diclofenac sodium (DS) microtablet was formulated. The microtablets contained various polymers such as ethylcellulose (EC) and hydroxypropylmethylcellulose (HPMC K15M), waxes such as compritol 888 ATO and tristearin as matrix former and prepared by wet granulation method. It was found that the flow rates of granules were decreased when the granules contained high amount of EC and combined EC with HPMC K15M or EC with glycerides waxes, indicating that type and amount of matrix former affected the physical properties of the DS granules. The physical properties of DS microtablets such as weight variation, friability, drug content, and content uniformity were passed the specification of official USP 24. In addition, it was noted that the hardness of DSmicrotablets was depended on the compression force and punch size. Due to its very low solubility in acid medium, DS microtablets exhibited lower than 5% release in 0.1 N HCl, while in phosphate buffer stage, percentage of DS dissolved could gradually increase over 24 hours. The compression forces from 400 to 1,200 lb had negligible effect on the drug release. On the other hand, increasing the tablet diameter decreased the release rate. Hence, the surface area had strong influence on the drug release pattern. Higher DS content gave faster release rate, increasing the proportion of waxes to EC ratio decreased the release rate, while combining EC with HPMC K15M exhibited opposite effect. Therefore, the sustained effect was depended on the types and amount of matrix former. Furthermore, the release model of all formulations was best fit the first-order plot and the mechanism of release was Super Case II transport. The release models of all prepared microtablets were also assessed in comparison with a commercial product (Voltarenา SR 75 mg). It was found that the drug release profiles of DS microtablets were different to that of Voltaren SR tablet.

บรรณานุกรม :
Surawee Chantorn . (2546). Effect of processing and formulation variables on the release Diclofenac Sodium from Microtablets.
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย.
Surawee Chantorn . 2546. "Effect of processing and formulation variables on the release Diclofenac Sodium from Microtablets".
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย.
Surawee Chantorn . "Effect of processing and formulation variables on the release Diclofenac Sodium from Microtablets."
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย, 2546. Print.
Surawee Chantorn . Effect of processing and formulation variables on the release Diclofenac Sodium from Microtablets. กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย; 2546.