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Amplification of 1q21 and other abnormalities in multiple myeloma patients from a tertiary hospital in Singapore

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Amplification of 1q21 and other abnormalities in multiple myeloma patients from a tertiary hospital in Singapore
นักวิจัย : Lim, Alvin S. T. , Krishnan, Sathish , Lim, Tse Hui , See, Karen , Ng, Yit Jun , Tan, Yu Min , Choo, Natasha , Lau, Lai Ching , Tien, Sim Leng , Ma, Jun , Tan, Daryl
คำค้น : DRNTU::Science::Biological sciences.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : Lim, A. S. T., Krishnan, S., Lim, T. H., See, K., Ng, Y. J., Tan, Y. M., et al. (2013). Amplification of 1q21 and other abnormalities in multiple myeloma patients from a tertiary hospital in Singapore. Indian journal of hematology and blood transfusion, in press. , http://hdl.handle.net/10220/17402 , http://dx.doi.org/10.1007/s12288-013-0294-8
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Indian journal of hematology and blood transfusion
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Much effort has been made to stratify multiple myeloma patients for targeted therapy. However, responses have been varied and improved patient stratifications are needed. Forty-five diagnostic samples from multiple myeloma patients (median age 65 years) were stratified cytogenetically as 15 having non-hyperdiploidy, 20 having hyperdiploidy and 10 having a normal karyotype. Fluorescence in situ hybridization (FISH) assays with FGFR3/IGH, CCND1/IGH, IGH/MAF, RB1 and TP53 probes on bone marrow samples showed that IGH rearrangements were the most common abnormality in the non-hyperdiploid group but these were also found among hyperdiploid patients and patients with normal cytogenetics. Of these, FGFR3/IGH rearrangements were most frequent. Deletion of RB1/monosomy 13 was the most common genetic abnormality across the three groups and was significantly higher among non-hyperdiploid compared to hyperdiploid patients. On the other hand, the study recorded a low incidence of TP53 deletion/monosomy 17. The FGFR3/IGH fusion was frequently seen with RB1 deletion/monosomy 13. FISH with 1p36/1q21 and 6q21/15q22 probes showed that amplification of 15q22 was seen in all of the hyperdiploid patients while amplification of 1q21, Amp(1q21), characterized non-hyperdiploid patients. In contrast, deletions of 1p36 and 6q21 were very rare events. Amp(1q21), FGFR3/IGH fusion, RB1 deletion/monosomy 13, and even TP53 deletion/monosomy 17 were seen in some hyperdiploid patients, suggesting that they have a less than favorable prognosis and require closer monitoring.

บรรณานุกรม :
Lim, Alvin S. T. , Krishnan, Sathish , Lim, Tse Hui , See, Karen , Ng, Yit Jun , Tan, Yu Min , Choo, Natasha , Lau, Lai Ching , Tien, Sim Leng , Ma, Jun , Tan, Daryl . (2556). Amplification of 1q21 and other abnormalities in multiple myeloma patients from a tertiary hospital in Singapore.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lim, Alvin S. T. , Krishnan, Sathish , Lim, Tse Hui , See, Karen , Ng, Yit Jun , Tan, Yu Min , Choo, Natasha , Lau, Lai Ching , Tien, Sim Leng , Ma, Jun , Tan, Daryl . 2556. "Amplification of 1q21 and other abnormalities in multiple myeloma patients from a tertiary hospital in Singapore".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lim, Alvin S. T. , Krishnan, Sathish , Lim, Tse Hui , See, Karen , Ng, Yit Jun , Tan, Yu Min , Choo, Natasha , Lau, Lai Ching , Tien, Sim Leng , Ma, Jun , Tan, Daryl . "Amplification of 1q21 and other abnormalities in multiple myeloma patients from a tertiary hospital in Singapore."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print.
Lim, Alvin S. T. , Krishnan, Sathish , Lim, Tse Hui , See, Karen , Ng, Yit Jun , Tan, Yu Min , Choo, Natasha , Lau, Lai Ching , Tien, Sim Leng , Ma, Jun , Tan, Daryl . Amplification of 1q21 and other abnormalities in multiple myeloma patients from a tertiary hospital in Singapore. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.