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Deactivation of the parvalbumin-positive interneurons in the hippocampus after fear-like behaviour following electrical stimulation of the dorsolateral periaqueductal gray of rats.

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Deactivation of the parvalbumin-positive interneurons in the hippocampus after fear-like behaviour following electrical stimulation of the dorsolateral periaqueductal gray of rats.
นักวิจัย : Temel, Yasin. , Blokland, Arjan. , Lim, Lee Wei.
คำค้น : -
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Temel, Y., Blokland, A.,& Lim, L. W. (2012). Deactivation of the parvalbumin-positive interneurons in the hippocampus after fear-like behaviour following electrical stimulation of the dorsolateral periaqueductal gray of rats. Behavioural Brain Research, 233(2), 322-325. , 0166-4328 , http://hdl.handle.net/10220/12666 , http://dx.doi.org/10.1016/j.bbr.2012.05.029
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Behavioural brain research
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The majority of patients with panic disorder express a fearful sensation when encountered with panic-related cues. A subpopulation of GABAergic interneurons in the hippocampus has been demonstrated in the regulation of behavioural learning, especially during the contextual fear-conditioning. Here, we examined the influence of panic/fear response induced by deep brain stimulation (DBS) of the periaqueductal gray on these hippocampal parvalbumin-positive interneurons. We found that fear-like behaviour did not change the number of c-Fos immunoreactive and parvalbumin-positive cells. However, a remarkable decrease of c-Fos and parvalbumin co-localization was shown in the hippocampal regions when compared to non-stimulated sham animals. In line with previous studies, our results support the hypothesis that GABAergic regulation resulted in enhanced behavioural reactivity to fear conditioning. In conclusion, our findings indicate that the inhibition of this subpopulation of hippocampal parvalbumin-positive interneurons induced a long lasting anxiety- or fear-like behaviour.

บรรณานุกรม :
Temel, Yasin. , Blokland, Arjan. , Lim, Lee Wei. . (2555). Deactivation of the parvalbumin-positive interneurons in the hippocampus after fear-like behaviour following electrical stimulation of the dorsolateral periaqueductal gray of rats..
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Temel, Yasin. , Blokland, Arjan. , Lim, Lee Wei. . 2555. "Deactivation of the parvalbumin-positive interneurons in the hippocampus after fear-like behaviour following electrical stimulation of the dorsolateral periaqueductal gray of rats.".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Temel, Yasin. , Blokland, Arjan. , Lim, Lee Wei. . "Deactivation of the parvalbumin-positive interneurons in the hippocampus after fear-like behaviour following electrical stimulation of the dorsolateral periaqueductal gray of rats.."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Temel, Yasin. , Blokland, Arjan. , Lim, Lee Wei. . Deactivation of the parvalbumin-positive interneurons in the hippocampus after fear-like behaviour following electrical stimulation of the dorsolateral periaqueductal gray of rats.. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.