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A New Class Of Potential Chloroquine Resistance Reversal Agents For Plasmodia: Syntheses And Biological Evaluation 1-[(3’-Diethylaminopropyl)-3-(Substituted Phenylmethylene)-Pyrrolidines

รายละเอียด

ชื่อเรื่อง : A New Class Of Potential Chloroquine Resistance Reversal Agents For Plasmodia: Syntheses And Biological Evaluation 1-[(3’-Diethylaminopropyl)-3-(Substituted Phenylmethylene)-Pyrrolidines
นักวิจัย : Batra, Sanjay , Srivastava, Pratima , Roy, Kamal , Pandey, V C , Bhaduri, A P
คำค้น : -
หน่วยงาน : -
ผู้ร่วมงาน : -
ปีพิมพ์ : 2543
อ้างอิง : J. Med. Chem., 43, 3428-3433 , http://hdl.handle.net/123456789/79
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CDRI Communication No. 6024
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

1-[(3’-Diethylaminopropyl)-3-(substitutedphenylmethylene) pyrrolidines] were synthe-sized and evaluated for CQ resistant reversal activity. The compounds of the series elicit better biological response than their phenyl methyl analogues in general. The most active compound 4b has been evaluated in vivo in details and the results are presented. The possible mode of action of the compounds of this series is by inhibition of the enzyme heme oxygenase, thereby increasing the levels of heme and hemozoin, which are lethal to the parasite.

บรรณานุกรม :
Batra, Sanjay , Srivastava, Pratima , Roy, Kamal , Pandey, V C , Bhaduri, A P . (). A New Class Of Potential Chloroquine Resistance Reversal Agents For Plasmodia: Syntheses And Biological Evaluation 1-[(3’-Diethylaminopropyl)-3-(Substituted Phenylmethylene)-Pyrrolidines.
    : .
Batra, Sanjay , Srivastava, Pratima , Roy, Kamal , Pandey, V C , Bhaduri, A P . . "A New Class Of Potential Chloroquine Resistance Reversal Agents For Plasmodia: Syntheses And Biological Evaluation 1-[(3’-Diethylaminopropyl)-3-(Substituted Phenylmethylene)-Pyrrolidines".
    : .
Batra, Sanjay , Srivastava, Pratima , Roy, Kamal , Pandey, V C , Bhaduri, A P . "A New Class Of Potential Chloroquine Resistance Reversal Agents For Plasmodia: Syntheses And Biological Evaluation 1-[(3’-Diethylaminopropyl)-3-(Substituted Phenylmethylene)-Pyrrolidines."
    : , . Print.
Batra, Sanjay , Srivastava, Pratima , Roy, Kamal , Pandey, V C , Bhaduri, A P . A New Class Of Potential Chloroquine Resistance Reversal Agents For Plasmodia: Syntheses And Biological Evaluation 1-[(3’-Diethylaminopropyl)-3-(Substituted Phenylmethylene)-Pyrrolidines. : ; .