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Combinatorial synthesis and biological evaluation of isoxazole-based libraries as antithrombotic agents

รายละเอียด

ชื่อเรื่อง : Combinatorial synthesis and biological evaluation of isoxazole-based libraries as antithrombotic agents , Corrigendum to ‘‘Combinatorial Synthesis and Biological Evaluation of Isoxazole-Based Libraries as Antithrombotic Agents’’ [Bioorg. Med. Chem. Lett. 12 (2002) 1905]
นักวิจัย : Batra, Sanjay , Srinivasan, T , Rastogi, S K , Kundu, Bijoy , Patra, A , Bhaduri, A P , Dikshit, Madhu
คำค้น : -
หน่วยงาน : -
ผู้ร่วมงาน : -
ปีพิมพ์ : 2545
อ้างอิง : Bioorg. Med. Chem. Lett. 12, 1905-1908, Bioorganic & Medicinal Chemistry Letters 12 (2002) 3349 , http://hdl.handle.net/123456789/80
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CDRI Communication no. 6071
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The 3-substitutedphenyl-5-isoxazolecarboxaldehydes have been identified as activated aldehydes for the generation of isoxazole-based combinatorial libraries on solid phase through automation. Three highly functionalized isoxazole-based libraries comprising of 32, 96 and 45 compounds each have been synthesized in parallel format using Baylis Hillman reaction, Michael addition, reductive amination and alkylation reactions. With an objective of lead generation all the three libraries were evaluated for their antithrombin activity in vivo.

บรรณานุกรม :
Batra, Sanjay , Srinivasan, T , Rastogi, S K , Kundu, Bijoy , Patra, A , Bhaduri, A P , Dikshit, Madhu . (). Combinatorial synthesis and biological evaluation of isoxazole-based libraries as antithrombotic agents.
    : .
Batra, Sanjay , Srinivasan, T , Rastogi, S K , Kundu, Bijoy , Patra, A , Bhaduri, A P , Dikshit, Madhu . . "Combinatorial synthesis and biological evaluation of isoxazole-based libraries as antithrombotic agents".
    : .
Batra, Sanjay , Srinivasan, T , Rastogi, S K , Kundu, Bijoy , Patra, A , Bhaduri, A P , Dikshit, Madhu . "Combinatorial synthesis and biological evaluation of isoxazole-based libraries as antithrombotic agents."
    : , . Print.
Batra, Sanjay , Srinivasan, T , Rastogi, S K , Kundu, Bijoy , Patra, A , Bhaduri, A P , Dikshit, Madhu . Combinatorial synthesis and biological evaluation of isoxazole-based libraries as antithrombotic agents. : ; .