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Baylis-Hillman reaction assisted parallel synthesis of 3, 5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents

รายละเอียด

ชื่อเรื่อง : Baylis-Hillman reaction assisted parallel synthesis of 3, 5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents
นักวิจัย : Batra, Sanjay , Roy, Amrendra K , Patra, A , Bhaduri, A P , Surin, W R , Raghavan, S A V , Sharma, P , Kapoor, Kapil , Dikshit, Madhu
คำค้น : Baylis-Hillman reaction , Isoxazolecarbaldehyde , isoxazole , nucleophilic substitution , substituted piperazine , antithrombotic activity , platelet aggregation
หน่วยงาน : -
ผู้ร่วมงาน : -
ปีพิมพ์ : 2547
อ้างอิง : Bioorg. Med. Chem., 12(9), 2059-2077 , http://hdl.handle.net/123456789/34
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CDRI Communication No. 6468
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The solution phase parallel synthesis involving reactions of Baylis-Hillman products of 3-substituted-5-isoxazolecarbaldehydes with nucleophiles and their in vivo antithrombotic evaluations are described along with the results of in vitro platelet aggregation inhibition assay of a few compounds. Results of the detailed evaluation of one of the compounds as an inhibitor of platelet aggregation are also presented.

บรรณานุกรม :
Batra, Sanjay , Roy, Amrendra K , Patra, A , Bhaduri, A P , Surin, W R , Raghavan, S A V , Sharma, P , Kapoor, Kapil , Dikshit, Madhu . (). Baylis-Hillman reaction assisted parallel synthesis of 3, 5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents.
    : .
Batra, Sanjay , Roy, Amrendra K , Patra, A , Bhaduri, A P , Surin, W R , Raghavan, S A V , Sharma, P , Kapoor, Kapil , Dikshit, Madhu . . "Baylis-Hillman reaction assisted parallel synthesis of 3, 5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents".
    : .
Batra, Sanjay , Roy, Amrendra K , Patra, A , Bhaduri, A P , Surin, W R , Raghavan, S A V , Sharma, P , Kapoor, Kapil , Dikshit, Madhu . "Baylis-Hillman reaction assisted parallel synthesis of 3, 5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents."
    : , . Print.
Batra, Sanjay , Roy, Amrendra K , Patra, A , Bhaduri, A P , Surin, W R , Raghavan, S A V , Sharma, P , Kapoor, Kapil , Dikshit, Madhu . Baylis-Hillman reaction assisted parallel synthesis of 3, 5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents. : ; .