ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

Effects of entrapped compounds and chemical structure and concentration of Brij on formation and characteristics of liposomes

หน่วยงาน จุฬาลงกรณ์มหาวิทยาลัย

รายละเอียด

ชื่อเรื่อง : Effects of entrapped compounds and chemical structure and concentration of Brij on formation and characteristics of liposomes
นักวิจัย : Amaraporn Roopdee
คำค้น : Liposomes , ไลโปโซม
หน่วยงาน : จุฬาลงกรณ์มหาวิทยาลัย
ผู้ร่วมงาน : Pornpen Werawatganone , Walaisiri Muangsiri , Chulalongkorn University. Faculty of Pharmaceutical Sciences
ปีพิมพ์ : 2551
อ้างอิง : http://cuir.car.chula.ac.th/handle/123456789/34509
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Thesis (M.Sc. in Pharm)--Chulalongkorn University, 2008

The purposes of this study were to study the influence of chemical structure and concentration of Brij® on liposome formation and to investigate effect of entrapped compounds on formation and characteristic of liposomes. The results showed that, Brij® 30, Brij® 35 and Brij® 72 could be employed in preparation of liposomes using thin film hydration method. Blank liposomes (PC liposomes) and liposomes containing Brij® (PC-Brij® liposomes) were characterized for various parameters including vesicle shape and morphology, size and size distribution. The obtained PC-Brij® liposomes were characterized as multilamellar vesicles (MLVs) with smooth surface. Size differences of PC-Brij® liposomes were discussed on difference in physicochemical properties of Brij®. PC-Brij® liposomes composed of Brij® 30 at 20 % w/w of total lipid content (L_30/20) and PC-Brij® liposomes composed of Brij® 72 at 15 % w/w of total lipid content (L_72/15) were chosen for further study. Vesicle size reduction was observed from PC and PC-Brij® liposomes loaded with griseofulvin when compared to the corresponding blank PC and PC-Brij® liposomes. Percent griseofulvin entrapment efficiencies were related to vesicle size. Hydrophobicity of griseofulvin was expected to directly affect the bilayer characteristic. Griseofulvin was well retained inside the vesicles due to its hydrophobicity nature with approximately 20 % leakage after storage at 4 °C for 1 month. Sizes of PC and PC-Brij® liposomes loaded with hydrophilic carboxyfluorescein were comparable to the corresponding blank PC and PC-Brij® liposomes. % Carboxyfluorescein entrapment efficiencies were proportional to vesicle size. Leakage of carboxyfluorecein from all formulations was observed probably due to lyze and leak of vesicles.

บรรณานุกรม :
Amaraporn Roopdee . (2551). Effects of entrapped compounds and chemical structure and concentration of Brij on formation and characteristics of liposomes.
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย.
Amaraporn Roopdee . 2551. "Effects of entrapped compounds and chemical structure and concentration of Brij on formation and characteristics of liposomes".
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย.
Amaraporn Roopdee . "Effects of entrapped compounds and chemical structure and concentration of Brij on formation and characteristics of liposomes."
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย, 2551. Print.
Amaraporn Roopdee . Effects of entrapped compounds and chemical structure and concentration of Brij on formation and characteristics of liposomes. กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย; 2551.