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CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia

หน่วยงาน National Institute Of Oceanography (NIO), India

รายละเอียด

ชื่อเรื่อง : CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia
นักวิจัย : Ravindran, C. , Cheng, Y.-C. , Liang, S.-M.
คำค้น : microglial cells , oligodeoxynucleotides , Amyloid beta , CpG-ODNs
หน่วยงาน : National Institute Of Oceanography (NIO), India
ผู้ร่วมงาน : -
ปีพิมพ์ : 2553
อ้างอิง : Cellular Immunology, vol.260(2); 113-118 , http://drs.nio.org/drs/handle/2264/3573
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Unmethylated CpG oligodeoxynucleotides (CpG-ODNs) interact with Toll-like receptor (TLR) 9 to activate macrophage/microglia in central nervous system (CNS). The potential involvement of the chemokine CCL9 and its receptor CCR1 in the effects of CpG-ODNs on macrophage/microglial cells are investigated. CpG-ODNs enhanced the expression of TLR9 mRNA of RAW264.7 macrophage and BV2 microglia cells time dependently. The expression of CCL9 of macrophages/microglia showed different responsiveness upon stimulation with a variety of CpG-ODN sequences. The CpG-ODNs-mediated induction of CCL9 was TLR9/MyD88 dependent and associated with activation of stress kinases, particularly ERK, p38 MAPK and PI3K. The expression of CCR1 was also significantly increased by CpG-ODNs that increased CCL9 expression. These results reveal the potential involvement of CCL9 and CCR1 in regulation of macrophage and microglial cells by CpG-ODNs and may help improving our understanding about the role of the chemokine/chemokine receptor pairs in macrophage/microglia under physiologic and pathologic conditions

บรรณานุกรม :
Ravindran, C. , Cheng, Y.-C. , Liang, S.-M. . (2553). CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia.
    : National Institute Of Oceanography (NIO), India.
Ravindran, C. , Cheng, Y.-C. , Liang, S.-M. . 2553. "CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia".
    : National Institute Of Oceanography (NIO), India.
Ravindran, C. , Cheng, Y.-C. , Liang, S.-M. . "CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia."
    : National Institute Of Oceanography (NIO), India, 2553. Print.
Ravindran, C. , Cheng, Y.-C. , Liang, S.-M. . CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia. : National Institute Of Oceanography (NIO), India; 2553.