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A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines

หน่วยงาน Universiti Sains Malaysia, Malaysia

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ชื่อเรื่อง : A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines
นักวิจัย : I. Almansour, Abdulrahman , Kumar, Raju Suresh , Arumugam, Natarajan , Basiri, Alireza , Kia, Yalda , Ali, Mohamed Ashraf , Farooq, Mehvish , Murugaiyah, Vikneswaran
คำค้น : QD1-999 Chemistry , R735-854 Medical education. Medical schools. Research , RS1-441 Pharmacy and materia medica
หน่วยงาน : Universiti Sains Malaysia, Malaysia
ผู้ร่วมงาน : -
ปีพิมพ์ : 2558
อ้างอิง : http://eprints.usm.my/38014/1/A_Facile_Ionic_Liquid_Promoted_Synthesis%2C_Cholinesterase_Inhibitory.pdf , I. Almansour, Abdulrahman and Kumar, Raju Suresh and Arumugam, Natarajan and Basiri, Alireza and Kia, Yalda and Ali, Mohamed Ashraf and Farooq, Mehvish and Murugaiyah, Vikneswaran (2015) A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines. Molecules, 20 (2). pp. 2296-2309. ISSN 1420-3049
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : https://doi.org/10.3390/molecules20022296 , http://eprints.usm.my/38014/
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC50 value of 1.57 μM against acethylcholinesterase (AChE). Molecular docking simulation for the most active compound was employed with the aim of disclosing its binding mechanism to the active site of AChE receptor.

บรรณานุกรม :
I. Almansour, Abdulrahman , Kumar, Raju Suresh , Arumugam, Natarajan , Basiri, Alireza , Kia, Yalda , Ali, Mohamed Ashraf , Farooq, Mehvish , Murugaiyah, Vikneswaran . (2558). A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines.
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia.
I. Almansour, Abdulrahman , Kumar, Raju Suresh , Arumugam, Natarajan , Basiri, Alireza , Kia, Yalda , Ali, Mohamed Ashraf , Farooq, Mehvish , Murugaiyah, Vikneswaran . 2558. "A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines".
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia.
I. Almansour, Abdulrahman , Kumar, Raju Suresh , Arumugam, Natarajan , Basiri, Alireza , Kia, Yalda , Ali, Mohamed Ashraf , Farooq, Mehvish , Murugaiyah, Vikneswaran . "A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines."
    กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia, 2558. Print.
I. Almansour, Abdulrahman , Kumar, Raju Suresh , Arumugam, Natarajan , Basiri, Alireza , Kia, Yalda , Ali, Mohamed Ashraf , Farooq, Mehvish , Murugaiyah, Vikneswaran . A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines. กรุงเทพมหานคร : Universiti Sains Malaysia, Malaysia; 2558.