ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

Increased oxidative metabolism is associated with erythroid precursor expansion in β 0-thalassaemia/Hb E disease

หน่วยงาน มหาวิทยาลัยเชียงใหม่

รายละเอียด

ชื่อเรื่อง : Increased oxidative metabolism is associated with erythroid precursor expansion in β 0-thalassaemia/Hb E disease
นักวิจัย : Leecharoenkiat,A. , Wannatung,T. , Lithanatudom,P. , Svasti,S.L. , Fucharoen,S. , Chokchaichamnankit,D. , Srisomsap,C. , Smith,D.R.
คำค้น : Cell Biology , Hematology , Molecular Medicine , Molecular Biology
หน่วยงาน : มหาวิทยาลัยเชียงใหม่
ผู้ร่วมงาน : -
ปีพิมพ์ : 2554
อ้างอิง : 10799796 , 2-s2.0-80053386941 , 10.1016/j.bcmd.2011.06.005 , 21783389 , http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80053386941&origin=inward , http://cmuir.cmu.ac.th/handle/6653943832/38602
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Erythropoiesis in β 0-thalassaemia/Hb E patients, the most common variant form of β-thalassaemia in Southeast Asia, is characterized by accelerated differentiation and over-expansion of erythroid precursor cells. The mechanism driving this accelerated expansion and differentiation remain unknown. To address this issue a proteomic analysis was undertaken to firstly identify proteins differentially expressed during erythroblast differentiation and a second analysis was undertaken to identify proteins differentially expressed between β 0-thalassaemia/Hb E erythroblasts and control erythroblasts. The majority of proteins identified as being differentially expressed between β 0-thalassaemia/Hb E and control erythroblasts were constituents of the glycolysis/TCA pathway and levels of oxidative stress correlated with the degree of erythroid expansion. A model was constructed linking these observations with previous studies showing increased phosphorylation of ERK1/2 in thalassemic erythroblasts which predicted the increased activation of PKA, PKB and PKC which Western analysis confirmed. Inhibition of PKA or PKC reduced β 0-thalassaemia/Hb E erythroblast differentiation and/or expansion. We propose that increased expansion and differentiation of β 0-thalassaemia/Hb E erythroblasts occur as a result of feedback loops acting through increased oxidative metabolism. © 2011 Elsevier Inc.

บรรณานุกรม :
Leecharoenkiat,A. , Wannatung,T. , Lithanatudom,P. , Svasti,S.L. , Fucharoen,S. , Chokchaichamnankit,D. , Srisomsap,C. , Smith,D.R. . (2554). Increased oxidative metabolism is associated with erythroid precursor expansion in β 0-thalassaemia/Hb E disease.
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Leecharoenkiat,A. , Wannatung,T. , Lithanatudom,P. , Svasti,S.L. , Fucharoen,S. , Chokchaichamnankit,D. , Srisomsap,C. , Smith,D.R. . 2554. "Increased oxidative metabolism is associated with erythroid precursor expansion in β 0-thalassaemia/Hb E disease".
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ .
Leecharoenkiat,A. , Wannatung,T. , Lithanatudom,P. , Svasti,S.L. , Fucharoen,S. , Chokchaichamnankit,D. , Srisomsap,C. , Smith,D.R. . "Increased oxidative metabolism is associated with erythroid precursor expansion in β 0-thalassaemia/Hb E disease."
    เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ , 2554. Print.
Leecharoenkiat,A. , Wannatung,T. , Lithanatudom,P. , Svasti,S.L. , Fucharoen,S. , Chokchaichamnankit,D. , Srisomsap,C. , Smith,D.R. . Increased oxidative metabolism is associated with erythroid precursor expansion in β 0-thalassaemia/Hb E disease. เชียงใหม่ : มหาวิทยาลัยเชียงใหม่ ; 2554.